Introduction

Welcome back nude followers, today we are summarizing an episode by Nathalie Niddam from the podcast "LONGEVITY" featuring Dr. Paniz Jasbi, the co-founder of Theriome. This episode delves into advanced metabolomic testing, the Aristotle test, and its revolutionary impact on health optimization.

• Guest and Main Theme: Dr. Paniz Jasbi discusses metabolomics, spermidine, microbiome, and the Aristotle test.
• Key Takeaways: Listeners will learn about the cutting-edge field of metabolomics, its application in personalized medicine, and how it can provide deep insights into an individual's health.

The Aristotle Test and Metabolomics

The Aristotle test, developed by Theriome, is a metabolomics test that offers unparalleled health information through deep phenotyping.

• Metabolomic Testing: The test analyzes 126 Sentinel metabolites related to cellular physiology, covering 68% of all known human canonical pathways.
• Sample Type: The test uses a dry blood spot, analyzing whole blood cells and plasma to provide a comprehensive look at chronic expression of metabolites.
• AI and Machine Learning: The analysis involves constructing over 15,000 models using AI, including random forest, support vector machines, and convolutional neural networks.
• Personalized Medicine: The test is designed for "n of one" studies, providing insightful and actionable data for an individual using Bayesian framework and prior/post probabilities.
• Health Domains: The test reports on 12 health domains, including aging, mitochondrial health, liver health, and nutritional status, among others.

Spermidine and Aging

Spermidine is a key metabolite discussed in the context of aging.

• Role in Aging: Spermidine addresses several hallmarks of aging and accounts for a significant proportion of variance in aging models, making it a crucial biomarker.
• Measurement: Spermidine levels are assessed in whole blood, which includes red blood cells and plasma, providing a comprehensive view of its chronic expression.
• Statistical Significance: Spermidine accounts for 22% of aging variance in the models, avoiding overfitting by not relying on multiple other metabolites.
• Related Metabolites: Other polyamines like putrescine and cadaverine are also important biomarkers, with cadaverine showing a linear increase with age.

Mitochondrial Health

Mitochondrial function is a critical aspect of the test.

• Direct Assessment: The Aristotle test directly assesses mitochondrial function by measuring products of the TCA cycle and electron transport chain, something not commonly available in traditional diagnostic labs.
• Metabolites Measured: The test measures five products of the TCA cycle (citric acid, alpha-ketoglutarate, fumaric acid, malic acid, and succinic acid) and adenosine, a component of ATP.
• Enzyme Targeting: By identifying metabolic perturbations, the test can target specific enzymes to restore mitochondrial homeostasis.

Microbiome and Integrated Testing

The microbiome is an integral part of the overall health assessment.

• Microbiome Test: Theriome is developing the Ilia test, which uses shotgun metatranscriptomic sequencing to monitor 600 bugs at the species level, including fungi, archa, and parasites.
• Integration with Metabolomics: The future multiomic test will integrate both metabolic and microbiome data to provide insights into function, not just composition.
• Black Box: The microbiome is described as a "black box" due to its complexity, but ongoing research aims to unravel its importance in health.

Nutrition and Health Optimization

Nutrition plays a critical role in health optimization.

• Nutritional Index: The nutritional index is one of the 12 health domains assessed, with a focus on metabolites related to nutritional status and micronutrients.
• Case Studies: Nutrition interventions were key in case studies, such as a retired dentist with mercury poisoning and a cancer patient, where tailored nutrition plans helped in recovery and improvement.
• Food as Medicine: The test emphasizes the importance of nutrition, aligning with the philosophy that "food is medicine," and provides specific dietary recommendations based on metabolomic data.

Key Takeaways

• Personalized Medicine: The Aristotle test revolutionizes personalized medicine by providing deep insights into an individual's unique health needs.
• Advanced Testing: The test uses AI and machine learning to analyze metabolomic data, offering a comprehensive health profile.
• Holistic Approach: The integration of metabolomics, microbiome analysis, and nutritional insights provides a holistic view of health.
• Accessibility: Theriome aims to make this advanced testing accessible and affordable, reducing costs as operations become more efficient.
• Real-world Applications: The test has applications for individuals with complex health issues, athletes seeking performance optimization, and those looking to rebuild health after significant medical treatments.